Researchers from the Mayo Clinic have published an article in JAMA about the results of a recent case-control study of 212 patients (106 patients with inflammatory CNS events and 106 control participants without such events) suggesting that exposure to tumor necrosis factor inhibitors is associated with an increased risk of inflammatory central nervous system events such as optic neuritis, transverse myelitis and multiple sclerosis, and neuromyelitis optica spectrum disorder. The authors discuss some possible mechanisms to account for this paradoxical response including upregulation of TNF expression within the CNS. Patients with central demyelinating disease may want to discuss these findings with their neurologist before using tumor necrosis factor inhibitors.
Link to original article in JAMA
Link to original article in JAMA
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