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Is it possible that people could be at greater risk for toxic effects when they are exposed to chemical mixtures than when they are exposed to the same chemicals at the same concentrations individually?

8/3/2018

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According to Professor Andreas Kortenkamp, of Brunel University "An increasing body of science shows a neglect of mixture effects can cause chemical risks to be underestimated".  Regulators have long operated under the assumption that if the concentration of each chemical in a mixture does not exceed the recommended exposure limits, that risk for toxicity is low.  But, when chemicals share common mechanisms of action they can produce additive or synergistic effects even at exposure leaves below current regulatory limits.  The logic behind additive and synergistic effects on the central nervous system is best exemplified by the consequences of drinking alcohol after ingesting benzodiazepines.  Since both chemicals act to enhance inhibitory neurotransmission, their combined effect on behavior and consciousness will be greater than that which occurs the same dose of either chemical alone. Physicians and toxicologists who work in Emergency Departments are well aware of this type of interaction.  So why can't those involved in creating regulatory policies for chemical constituents of paints, solvents, and pesticides create policies that anticipate these same risks?  The answer may be due in part to the fact that unlike alcoholic beverage and benzodiazepines, industrial solvents and pesticides are "not intended for human consumption" and because proper industrial hygiene practices are expected to be sufficient to reduced exposure to levels below the current occupational exposure limits.   

Link to original story appearing in Medicalxpress
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Neurotoxicants.com is strictly an information and news website about the associations between chemical exposure and neurological disease. The information provided on this site is meant to complement and not replace any advice or information from your healthcare professional. This content is not intended to be a substitute for professional medical advice or treatment.  Always seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.  While every care has been exercised in compiling and publishing the data contained in these pages, Neurotoxicants.com accepts no responsibility for errors or omissions to of the information provided on this website. Neurotoxicants.com cannot be held liable for typographical errors, layout error or misinformation contained herein.  Copyright © 2015-2022, Dr. Marcia H. Ratner, DABT, Proprietor and Principal Consultant, D.B.A. Neurotoxicants.com is registered with Dun and Bradstreet.  All Rights Reserved. Privately funded; Neurotoxicants.com does not accept or host paid advertising.  Neurotoxicants.com does not accept payment from any external influences which could affect the objectivity of the editorial content of this website.

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