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Are flight attendants at increased risk for ALS? If so why?

7/22/2016

A new study by Pinkerton and colleagues published in the American Journal of Industrial Medicine suggests that flight attendants are at increased risk for developing amyotrophic lateral sclerosis (ALS). Stratification of subjects by exposure duration did not reveal a dose response relationship. Flight attendants are at increased risk for exposures to pesticides, exposure to which has also been implicated as a risk factor for ALS. There was no increase risk for other neurodegenerative diseases such as Parkinson's disease.

Link to abstract of article in PubMed

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Role of pesticide induced α-synuclein expression in Parkinson's disease.

7/8/2016

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UCLA researchers have shown that exposure of zebra fish embryos to the dithiocarbamate fungicide ziram is associated with selective loss of the dopaminergic neurons and swimming impairments. Researches also found that ziram promoted formation of aggregates of γ1 synuclein, the functional homologue of α-synuclein in zebra fish. Depleting the γ1 synuclein from the zebrafish rendered them resistant to the ziram-induced toxicity in the dopaminergic neurons. These findings provide additional insight into the various mechanisms by which pesticides can interact with PD to modify disease progression.

Full news story in Parkinson's News Today

Link to Original article in Environmental Health Perspectives.

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Dr. Marcia Ratner shares and reviews the news.

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Last update: December 9, 2024

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Updated December 9, 2024