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Annovis Bio’s lead therapeutic ANVS401 improves function in Alzheimer’s and Parkinson’s

5/25/2021

Alzheimer's patients treated with ANVS401 showed significant improvement in cognition as measured by the Alzheimer's Disease Assessment Scale-Cognitive Subscale 11 (ADAS-Cog11). ANVS401 also significantly increased speed, coordination and motor function in Parkinson's patients enrolled in in this trial. ANVS401acts by improving axonal transport. Neurotoxic chemicals that disrupt axonal transport such as n-hexane are implicated in Parkinson's (see Pezzoli et al., 1995). Reducing exposure to these chemicals is associated with an increase in the age at onset of PD (see Pezzoli et al., 2014). These findings add additional support to the role of chemical exposures as disease modifiers in neurogenerative disease.

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Dr. Marcia Ratner shares and reviews the news.

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Last update: December 9, 2024

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Updated December 9, 2024