HealthDay News is reporting on the results of a study published in the Neurobiology of Aging suggesting that a mutation in the gene that code for the enzyme guanosine triphosphate cyclohydrolase-1 are implicated in cases of early onset Parkinson's disease. Catecholamine synthesizing enzymes such as guanosine triphosphate cyclohydrolase-1 are essential to normal motor function.
Dystonia and cock walk (toe walking) have been associated with manganese (Mn) exposure and with abnormal guanosine triphosphate cyclohydrolase-1 enzyme function. However, the interaction between Mn and guanosine triphosphate cyclohydrolase-1 function has not been fully elucidated. Divalent cations such as Mn2+ may inhibit the actviity of this enzyme (Fan and Brown 1976; Lista et al., 1976; Suzuki et al., 2004). Thus, future studies looking at the interactions between Mn exposure and guanosine triphosphate cyclohydrolase-1 enzyme function will be needed to parse out the interrelationships between Mn exposure and young onset PD.
Link to story in HealthDay News
Link to original article in Neurobiology of Aging
Dystonia and cock walk (toe walking) have been associated with manganese (Mn) exposure and with abnormal guanosine triphosphate cyclohydrolase-1 enzyme function. However, the interaction between Mn and guanosine triphosphate cyclohydrolase-1 function has not been fully elucidated. Divalent cations such as Mn2+ may inhibit the actviity of this enzyme (Fan and Brown 1976; Lista et al., 1976; Suzuki et al., 2004). Thus, future studies looking at the interactions between Mn exposure and guanosine triphosphate cyclohydrolase-1 enzyme function will be needed to parse out the interrelationships between Mn exposure and young onset PD.
Link to story in HealthDay News
Link to original article in Neurobiology of Aging
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