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Estrogen provides neuroprotection from ALS

10/17/2017

Neurology Advisor is reporting on recent findings by Rooney and colleagues published in the journal Neurology which suggest that Hormone Replacement Therapy (HRT) provides protection against ALS. This large case control study investigated subjects from Ireland, Italy, and the Netherlands. It is important to recognize that the most common form of HRT currently in use contains conjugated equine estrogens. Animal models suggest that estradiol (E2) provides neuroprotection (Groeneveld et al., 2004). Future studies will be needed to ascertain if E2 provides greater neuroprotection than estrone (E1) in female human subjects.

Link to original story in Neurology Advisor

Link to citation in Pubmed

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Dr. Marcia Ratner shares and reviews the news.

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Updated June 9, 2024