A group of researchers from Hawaii (Ross et al., 2019) investigating subjects from the Honolulu-Asia Aging Study (HAAS) has obsevered that the prevalence of Lewy neuropathology is nearly doubled in the presence versus the absence of heptachlor epoxide. Similar but slightly weaker associations were observed with two other organochlorine compounds such as hexachlorobenzene and α-chlordane which are both metabolized to heptachlor epoxide. These results were significant after exclusion of subjects with Parkinson's disease (PD). These findings implicate organochlorine compounds in the severity of Lewy neuropathology in subjects without PD. These findings also reveal a potential point of interaction between organochlorine exposure and a neuropathological process implicated in PD.
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