Link to original story in DailyMail
Link to CAT website
|Neurotoxicants.com, website of Dr. Marcia Ratner, expert, neurotoxicologist consulting in neurotoxicology, neurotoxins, neurotoxicants, and neurodegenerative disease||
Documenting VOCs in the workplace just got easier with introduction of game changing smartphone technology
The DailyMail is reporting on the release of a new smartphone from CAT that has an on-board air sensor made by the Sensirion. The new phone can detect Volatile Organic Compounds (VOCs) commonly found in paints, solvents, carpets, furniture and cleaning products. This phone is a potential game changer for anyone at risk of occupational or environmental exposures to VOCs. The data these phones can detect could potentially be used in future research aimed at understanding the role of neurotoxic VOCs in age-related neurodegenerative diseases as well.
Link to original story in DailyMail
Link to CAT website
The WKU Herald is reporting a story about ethnobotanist Paul Alan Cox whose research looking at the Ogimi people of rural Japan, suggests that a diet high in the amino acid L-serine may provide neuroprotection and even delay Alzheimer’s disease onset until very late in life. According to Cox “If we dose early, we can push off Alzheimer’s until you’re 115 to 120 years old,” According to the article, the "standard Ogimi diet consists of various types of seaweed, tofu and pork, and is the highest diet ever measured in L-serine". So should you load up on L-serine? Not so fast, but you may want to follow the clinical trials that are underway at Dartmouth-Hitchcock Medical Center.
Link to original story on WKU Herald website.
Link to FDA website for clinical Trial
An association between cadmium exposure and cognitive deficits in mice has been reported by Wang an colleagues. Exposure to cadmium was associated with impaired performance on hippocampus-dependent learning and memory tasks. An association between urinary cadmium levels and AD risk in human subjects has previously been reported by Peng and colleagues. Peng and colleagues suggested that toxicological studies were need to further elucidate their findings in humans. This new study in mice lends support to the hypothesis that there could be an interaction between these two factors shown to influence cognitive performance.
Link to Peng et al, 2017
Link to Wang et al, 2018
An article by Denis Thompson of Daily Health News which appears this month on WebMd calls our attention to the unfortunate fact that despite the billions of dollars and years of time spent on research, medical science has still not discovered any way to prevent or stop the progression of Alzheimer's disease. Many genes and proteins have been implicated in the disease and yet known of these has been found to be a druggable target suitable for effective disease prevention. The good news is that exercise and lifestyle changes may at least help to slow disease progression and delay onset.
Link to story on WedMD
The results of a new study by Gigante and colleagues (2017) published in the journal Parkinsonism & Related Disorders indicates that smoking is associated with an older in age-at-onset of motor signs in patients with Parkinson's disease. These new findings are consistent with our own also showing an older age at onset of PD among ever smokers (see Ratner et al. 2014). These data provide additional support for the hypothesis that exposure to chemicals can modify the progression of PD to influence age at onset of the disease.
Link to original article in PubMed
Neurology Advisor is reporting on recent findings by Rooney and colleagues published in the journal Neurology which suggest that Hormone Replacement Therapy (HRT) provides protection against ALS. This large case control study investigated subjects from Ireland, Italy, and the Netherlands. It is important to recognize that the most common form of HRT currently in use contains conjugated equine estrogens. Animal models suggest that estradiol (E2) provides neuroprotection (Groeneveld et al., 2004). Future studies will be needed to ascertain if E2 provides greater neuroprotection than estrone (E1) in female human subjects.
Link to original story in Neurology Advisor
Link to citation in Pubmed
Dr. Dimitri Krainc, the Aaron Montgomery Ward Professor and chair of neurology at Northwestern University and Dr. Lena Burbulla, a postdoctoral fellow in his laboratory, have shown that administration of antioxidants early in the disease process may break the degenerative cycle and improve neuronal function in Parkinson's disease. These authors identified a time-dependent pathological cascade in human neurons that begins with an increase in mitochondrial oxidative stress leading to accumulation of oxidized dopamine followed by lysosomal dysfunction and α-synuclein accumulation. This neuropathological toxic cascade was not observed in mouse model PD neurons. These results are consistent with my own research suggesting that compounds that increase oxidative stress have the potential to hasten disease progression resulting in a younger age at onset of disease. Most importantly, these observations point to an opportunity to slow subclinical disease onset through early changes in lifestyle such as avoiding exposure to toxic chemicals that increase oxidative stress.
Link to Original Story in Science Daily
Link to Article in Science
According to Glen Campbell's doctor Ronald Petersen in an interview with Today.com, saying alcohol or drug abuse caused Alzheimer’s disease is probably stretching it, "because it would mean that alcohol or drug usage actually leads to the development of plaques and tangles in the brain, and we clearly don’t know that". On the other hand, Petersen said, "severe alcohol use and certain drug behaviors can compromise the brain’s resilience. If we’ve had certain insults over our life — be it alcohol, drugs or head injuries — that may reduce the ability of the brain to compensate for the development of either aging or Alzheimer’s-type pathology. Other people who have not had those kinds insults might be able to compensate — their brains might be more plastic, more resilient — and stay functional at a higher level for a longer period."
Link to original story on Today.com
Another study reveals an association between occupational pesticide exposure and Parkinson's disease
A team of researchers from UCLA has reported on an association between occupational pesticide exposure and increased risk for PD. The study known as the Parkinson Environment Gene (PEG) study showed that risk was increased with occupational exposure to various classes of pesticides, indicating that no specific chemical but rather a shared mechanism of action may be involved. Unfortunately, this study lacked the statistical power to examine gene-pesticide interactions. Risk increased with increasing years of pesticide use, and job tasks resulting in the highest exposures to pesticides such as mixing and loading pesticides. These new findings are consistent with those reported by Ratner et al., 2015 and lend further support to the growing body of literature indicating that PD risk is modified by chemical exposures at concentrations that typically occur in occupational settings and that there is a dose response relationship between exposure and disease risk.
Link to study on PubMed
Professor Chris Exley, of Keele University is warning that survivors of the tragic Grenfell Tower fire in London were exposed to airborne aluminum which may increase their risk of Alzheimer's disease (AD) later in life. Although aluminum is toxic and was once thought to cause AD subsequent research has not supported the hypothesis that aluminum cause AD. Neuropathological findings have been reported in a patient exposed to aluminum in Camelford, Cornwall where 20 tonnes of aluminium sulphate was mistakenly discharged into the mains water supply (King et al., 2017). Bioaccumulation of aluminum in the brain has been associated with dialysis encephalopathy (Andrade et al., 2005). Increase aluminum concentration observed in brain tissue from subjects with familial Alzheimer's disease has rekindled the debate about the role this neurotoxic metal may play in this devastating neurodegenerative disease (MIzra et al., 2017).
Link to oringal story in Hippocratic Post
Dr. Marcia Ratner shares and reviews the news.