This video from Stamelou and colleagues (2012) which appears in the journal Movement Disorders shows the clinical features associated with manganese accumulation in the brain due to a mutation of the gene encoding for SLC30A10 (Solute Carrier Family 30, Member 10 gene, encoding a manganese transporter). Mutation of this gene is associated with very early onset familial forms of parkinsonism which should not be confused with idiopathic Parkinson's disease.The parkinsonian signs and symptoms associated with this mutation are similar to those seen in patients with a history of occupational exposure to manganese.
Note: This video is being posted here for educational purposes only and it is not intended to diagnosis or treat any disease. This material is being shared here with proper citation of the authors in accordance with the Creative Commons Deed.
Link to PubMed citation
Note: This video is being posted here for educational purposes only and it is not intended to diagnosis or treat any disease. This material is being shared here with proper citation of the authors in accordance with the Creative Commons Deed.
Link to PubMed citation
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